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Varsity Softball Coach: Mr. Joe Given
JV Softball Coach: Dave Flores
Athletic Director: Ms. Terri Sonniksen
| Day | Date | Opponent | @ | Site | JV time/Score | Varsity Time/Score |
| Tues | 3/2/10 | San Lorenzo Valley HS | @ | Notre Dame HS | 3-3/T | 7-3/W |
| Thurs | 3/4/10 | Aptos HS | @ | Notre Dame HS | 21-1/W | 8-3/W |
| Sat | 3/6/10 | Presentation HS | @ | Santa Teresa HS | 5-3/W | |
| Sat | 3/6/10 | St. Francis/Mt. View | @ | Santa Teresa HS | 4-5/L | |
| Tues | 3/9/10 | Presentation HS | @ | Notre Dame HS | 4-0/W | 4-2/W |
| Thurs | 3/11/10 | King City HS | @ | King City HS | 11-0/W | 4-0/W |
| Sat | 3/13/10 | LO Circle of ChampionsVarsity Tourney - Aragon HS | @ | Salinas Sports Complex | 2-6/L | |
| Sat | 3/13/10 | LO Circle of ChampionsVarsity Tourney - Watsonville HS | @ | Salinas Sports Complex | 6-0/W | |
| Tues | 3/16/10 | Archbishop Mitty HS | @ | Notre Dame HS | 0-3/L | |
| Thurs | 3/18/10 | Soquel HS | @ | Soquel HS | 10-9/W | |
| Fri | 3/19/10 | Archbishop Mitty HS | @ | Notre Dame HS | 12-5/W | |
| Sat | 3/20/10 | LO Circle of Champions -Carlmont HS | @ | Salinas Sports Complex | 5-4/W | |
| Sat | 3/20/10 | LO Circle of Champions- Gilroy HS | @ | Salinas Sports Complex | 2-1/W | |
| Tues | 3/23/10 | Alisal HS ** | @ | Notre Dame HS | 18-1/W | 24-1/W |
| Thurs | 3/25/10 | Salinas HS ** | @ | Salinas HS | 1-11/L | 3-4/L |
| Tues | 3/30/10 | North Salinas HS ** | @ | North Salinas HS | 19-0/W | 7-2/W |
| Thurs | 4/8/10 | Gilroy HS | @ | Notre Dame HS | 17-3/W | 6-1/W |
| Sat | 4/10/10 | ND/Steinbeck Varsity & JV Tourney | @ | Salinas Sports Complex | ||
| Mon | 4/12/10 | St. Francis HS-Watsonville | @ | St. Francis HS-Watsonville | cancelled | cancelled |
| Tues | 4/13/10 | Everett Alvarez HS ** | @ | Everett Alvarez HS | 20-0/W | 10-0/W |
| Thurs | 4/15/10 | Hollister HS ** | @ | Notre Dame HS | 4:30 | 4:30 |
| Sat | 4/17/10 | ND/Steinbeck Varsity & JV Tourney | @ | Salinas Sports Complex | 3rd Place | 1st Place |
| Thurs | 4/22/10 | Alisal HS ** | @ | Alisal HS | 4:30 | 4:30 |
| Mon | 4/26/10 | Salinas HS ** | @ | Notre Dame HS | 4:30 | 4:30 |
| Wed | 4/28/10 | North Salinas HS ** | @ | Notre Dame HS | 4:30 | 4:30 |
| Tues | 5/4/10 | Gilroy HS ** | @ | Gilroy HS | 4:30 | 4:30 |
| Thurs | 5/6/10 | Everett Alvarez HS ** | @ | Notre Dame HS | 4:30 | 4:30 |
| Tues | 5/11/10 | Hollister HS ** | @ | Hollister | 4:30 | 4:30 |
| Sat | 5/19/10 | CCS-First Section Event | @ | TBA | TBA | TBA |
| Sat | 5/29/10 | CCS-Finals | @ | TBA | ||
| ** League Game |